Streptozotocin (STZ)

Catalog No.S1312 Synonyms: NSC-85998

Streptozotocin (STZ) Chemical Structure

Molecular Weight(MW): 265.22

Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

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USD 297 In stock
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Cited by 2 Publications

1 Customer Review

  • Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. Data is expressed as mean ± SEM (n = 6). Statistical significances were determined using one way ANOVA followed by dunnetts post hoc test. ###p < 0.001 as compared with normal, *p < 0.05, *p < 0.01, ***p < 0.001 as compared to STZ control. TMS: telmisartan, MET: metformin, FLX: fluoxetine. The figure in parenthesis indicates the dose in mg/kg po.

    Pharmacol Rep, 2017, 69(2):358-364. Streptozotocin (STZ) purchased from Selleck.

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Choose Selective DNA alkylator Inhibitors

Biological Activity

Description Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.
In vitro

Streptozotocin directly methylates DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Free radicals are involved in the production of DNA and chromosome damage by Streptozotocin. [1] Streptozotocin is toxic to pancreatic beta cell. Exposed to 15 mM Streptozotocin for 1 hr followed by a 24 hrs recovery period induces apoptosis in murine pancreatic beta cell line, INS-1. Streptozotocin (30 mM) causes the cells to undergo necrosis (22%) as well as apoptosis (17%). [2]

In vivo Streptozotocin is often used to induce diabetes mellitus in experimental animals. Streptozotocin is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Streptozotocin (60 mg/kg) injection for 4 month induces rapid degranulation of beta cells without necrosis, development of cataracts and accumulation of glycogen in the proximal convoluted tubules of the kidney. Streptozotocin (100 mg/kg) produces lesions in the exocrine cells of the pancreas, and persistence of small, possibly secretory, granules in the Golgi zone of beta cells in rats of ‘Streptozotocin diabetes’. [3] Streptozotocin is found to be carcinogenic in rats, mice and hamster. A single administration of Streptozotocin is able to induce tumors in kidney, liver, lung, pancreas, uterine and liver tumors in hamster. Intraperitoneally injected with Streptozotocin (100-150 mg/kg) for normotensive Wistar Kyoto rats (WKY) for 12 months induces carcinogenesis with tumors incidence of 70% in liver, 20% in kidney and 10% in liver and kidney. [4]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (199.83 mM)
Water 53 mg/mL (199.83 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 265.22
Formula

C8H15N3O7

CAS No. 18883-66-4
Storage powder
in solvent
Synonyms NSC-85998

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02246127 Recruiting Neuroendocrine Tumors Grupo Espanol de Tumores Neuroendocrinos|European Neuroendocrine Tumor Society|Kantar Health|Novartis Pharmaceuticals October 27 2014 Phase 3
NCT02246127 Recruiting Neuroendocrine Tumors Grupo Espanol de Tumores Neuroendocrinos|European Neuroendocrine Tumor Society|Kantar Health|Novartis Pharmaceuticals October 27 2014 Phase 3
NCT00448136 Completed Neoplasms Hoffmann-La Roche July 2007 Phase 2
NCT00448136 Completed Neoplasms Hoffmann-La Roche July 2007 Phase 2
NCT00094497 Completed Carcinoma Adrenal Cortical Collaborative Group for Adrenocortical Carcinoma Treatment|German Federal Ministry of Education and Research|National Cancer Institute (NCI) June 2004 Phase 3
NCT00094497 Completed Carcinoma Adrenal Cortical Collaborative Group for Adrenocortical Carcinoma Treatment|German Federal Ministry of Education and Research|National Cancer Institute (NCI) June 2004 Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID