CAS No. 62996-74-1

Batch: Purity:99.61
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Staurosporine (STS) Chemical Structure
Chemical Structure
Check the Staurosporine (STS) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
CAS Number 62996-74-1
Molecular Formula

C28H26N4O3
Molecular Weight (MW) 466.53
SMILES CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChIKey HKSZLNNOFSGOKW-FYTWVXJKSA-N

Ordering Information

Biological Activity

Staurosporine (STS) is a potent, broad-spectrum ATP-competitive kinase inhibitor that targets protein kinase C (PKC), protein kinase A (PKA), and other protein kinases. By competing for ATP-binding domains, staurosporine disrupts downstream protein phosphorylation and signaling cascades involved in cell growth and survival. Consequently, staurosporine potently triggers apoptosis across diverse cell types, making it a widely utilized tool compound in kinase research and oncology studies. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 46 mg/mL (98.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.