CAS No. 106392-48-7
Batch:
Purity:99.78
Chemical Structure
Check the
ST 271
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 106392-48-7 | |
| Molecular Formula |
C16H20N2O2 |
|
| Molecular Weight (MW) | 272.34 | |
| SMILES | CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)N | |
| InChIKey | HMLQHJRJKQDTKW-LFYBBSHMSA-N |
Biological Activity
ST 271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor that acts as a blocker of tyrosine kinase-dependent signaling cascades. By attenuating PTK-mediated phosphorylation, ST 271 effectively inhibits phospholipase D (PLD) activity. This inhibition disrupts downstream PLD-mediated lipid signaling, affecting second messenger generation, cellular membrane remodeling, and key intracellular physiological pathways involved in signal transduction. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(198.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 54 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.