CAS No. 218156-96-8
| IUPAC Name | N-[2-piperidin-1-yl-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide | |
|---|---|---|
| CAS Number | 218156-96-8 | |
| Molecular Formula |
C18H18F3N3O |
|
| Molecular Weight (MW) | 349.35 | |
| SMILES | C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3 | |
| InChIKey | DWFGGOFPIISJIT-UHFFFAOYSA-N |
SRPIN340 is a selective ATP-competitive serine/arginine-rich protein kinase inhibitor that targets SRPK1 while exhibiting no significant inhibition across a broad panel of other protein kinases. By suppressing SRPK1 activity, SRPIN340 blocks downstream phosphorylation of serine/arginine-rich splicing factors, disrupting precursor mRNA alternative splicing pathways. This pathway modulation ultimately suppresses downstream phenotypes including viral propagation and tumor-associated angiogenesis. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 70 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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