CAS No. 2322245-49-6
Batch:
Purity:99.70
Chemical Structure
Check the
SRI-37330 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[[1-[6-(trifluoromethyl)quinazolin-4-yl]piperidin-3-yl]methyl]methanesulfonamide;hydrochloride | |
|---|---|---|
| CAS Number | 2322245-49-6 | |
| Molecular Formula |
C16H19F3N4O2S.ClH |
|
| Molecular Weight (MW) | 424.87 | |
| InChIKey | SIWGSSRKYJTJTF-UHFFFAOYSA-N |
SRI-37330 HCl is an orally bioavailable, anti-diabetic small-molecule inhibitor of thioredoxin-interacting protein (TXNIP) expression, exhibiting an ICoffor TXNIP mRNA expression in INS-1 cells. By suppressing TXNIP expression and signaling in pancreatic islets, SRI-37330 HCl inhibits alpha-cell glucagon secretion and glucagon action. Downstream, this inhibition decreases hepatic glucose production and effectively reverses hepatic steatosis. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.