CAS No. 1379686-29-9
Batch:
Purity:99.08
Chemical Structure
Check the
SR9011
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide | |
|---|---|---|
| CAS Number | 1379686-29-9 | |
| Molecular Formula |
C23H31ClN4O3S |
|
| Molecular Weight (MW) | 479.04 | |
| InChIKey | PPUYOYQTTWJTIU-UHFFFAOYSA-N |
Biological Activity
SRis a synthetic agonist targeting the nuclear hormone receptors REV-ERBα and REV-ERBβ. Activation of REV-ERB by SR9011 modulates circadian gene expression, thereby regulating cellular metabolic pathways and suppressing both autophagy and de novo lipogenesis. These downstream metabolic alterations selectively trigger apoptotic cell death in malignant cells and oncogene-induced senescent cells while sparing normal physiological tissues. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.