CAS No. 2505001-62-5
Batch:
Purity:99.77
Chemical Structure
Check the
SR18662
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-3-(3,4-dichlorophenyl)-N-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 2505001-62-5 | |
| Molecular Formula |
C16H19Cl2N3O4S |
|
| Molecular Weight (MW) | 420.31 | |
| SMILES | C[S](=O)(=O)N1CCN(CC1)C(=O)CNC(=O)/C=C/C2=CC(=C(Cl)C=C2)Cl | |
| InChIKey | WUJBXFXHDUVSFM-HWKANZROSA-N |
SR18662 is a potent inhibitor of Krüppel-like factor 5 (KLF5), designed as an optimized analog of ML264. By downregulating KLF5 expression and downstream signaling pathways, SR18662 effectively suppresses cell proliferation, reduces cell viability in multiple colorectal cancer cell lines, and promotes apoptotic cell death. These combined molecular effects position SR18662 as a valuable tool for investigating KLF5-driven oncogenic mechanisms and colorectal cancer biology. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.