CAS No. 1335106-03-0
Batch:
Purity:99.79
Chemical Structure
Check the
SR1001
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1335106-03-0 | |
|---|---|---|
| Molecular Formula |
C15H13F6N3O4S2 |
|
| Molecular Weight (MW) | 477.40 | |
| SMILES | CC1=C(SC(=N1)NC(=O)C)S(=O)(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O |
SR1001 is a synthetic inverse agonist targeting RORα (Ki of and RORγ (Ki of. By repressing RORα and RORγ transcriptional activity, SR1001 suppresses the expression of interleukin-17 and inhibits T helper 17 cell differentiation. Downstream suppression of these nuclear receptor signaling pathways reduces autoimmune inflammation and attenuates disease severity in animal models of autoimmune encephalomyelitis. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.