CAS No. 303126-97-8
Batch:
Purity:99.55
Chemical Structure
Check the
SR 0987
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide | |
|---|---|---|
| CAS Number | 303126-97-8 | |
| Molecular Formula |
C16H10ClF6NO2 |
|
| Molecular Weight (MW) | 397.70 | |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)Cl | |
| InChIKey | IZVBONMVWLTLNT-UHFFFAOYSA-N |
SR 0987 is a synthetic agonist targeting T cell-specific retinoic acid receptor-related orphan receptor gamma (RORγt). As a functional analog of SR 1078, it regulates nuclear receptor transcriptional activity to stimulate interleukin-17 (IL-17) expression while repressing programmed cell death protein 1 (PD-1). Through this downstream pathway modulation, SR 0987 enhances anti-tumor immunity and represents a potential therapeutic strategy for cancer immunotherapy. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(201.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 40 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.