CAS No. 1254944-66-5
Batch:
Purity:99.76
Chemical Structure
Check the
SR8278
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate | |
|---|---|---|
| CAS Number | 1254944-66-5 | |
| Molecular Formula |
C18H19NO3S2 |
|
| Molecular Weight (MW) | 361.48 | |
| SMILES | CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC | |
| InChIKey | UIEBLUZPSFAFOC-UHFFFAOYSA-N |
SR8278 is a synthetic, competitive antagonist of the nuclear receptor REV-ERBα. By blocking REV-ERB-mediated transcriptional repression, SR8278 alters circadian rhythm regulation and modulates downstream metabolic gene expression. Treatment with SR8278 increases the expression of key hepatic gluconeogenic enzymes, including glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), thereby influencing glucose metabolism. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.