CAS No. 2095432-55-4
| IUPAC Name | 1-[tert-butyl-[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)propan-2-ol | |
|---|---|---|
| CAS Number | 2095432-55-4 | |
| Molecular Formula |
C23 H30 N2 O2 |
|
| Molecular Weight (MW) | 366.50 | |
| SMILES | CC1=CC=C(C=C1)CN(CC(COC2=CC=CC3=C2C=CN3)O)C(C)(C)C | |
| InChIKey | BNRANURXPKRRKP-UHFFFAOYSA-N |
SR-18292 is a small-molecule inhibitor of PGC-1α gluconeogenic activity that promotes GCN5-mediated acetylation of PGC-1α. By increasing PGC-1α acetylation, SR-18292 suppresses its interaction with HNF4α and decreases hepatic gluconeogenic gene expression. This selective modulation leads to reduced glucose production in hepatocytes without disrupting mitochondrial oxygen consumption, demonstrating target-specific regulation of hepatic glucose output. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 73 mg/mL |
| Water | Insoluble |
| DMSO |
73 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 73 mg/mL |
| Water | Insoluble |
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- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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