CAS No. 126411-39-0

Batch: Purity:99.82
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SR-12813 Chemical Structure
Chemical Structure
Check the SR-12813 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol
CAS Number 126411-39-0
Molecular Formula

C24H42O7P2
Molecular Weight (MW) 504.53
SMILES CCOP(=O)(C(=CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C)P(=O)(OCC)OCC)OCC
InChIKey YQLJDECYQDRSBI-UHFFFAOYSA-N

Biological Activity

SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor. By binding to PXR, it activates transcriptional expression of xenobiotic-metabolizing enzymes such as CYP3A4, thereby modulating drug clearance and metabolic pathways. Simultaneously, SR-12813 suppresses cholesterol biosynthesis by enhancing the degradation of HMG-CoA reductase. These downstream actions regulate lipid homeostasis and cellular xenobiotic response phenotypes in hepatic models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (198.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Lehmann JM, et al. J Clin Invest. 1998;102(5):1016-23.

[2] Berkhout TA, et al. J Biol Chem. 1996;271(24):14376-82.

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Note: Technical data last updated: Sep 1, 2026.