CAS No. 146670-40-8

Batch: Purity:99.83
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SR 11237 Chemical Structure
Chemical Structure
Check the SR 11237 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid
CAS Number 146670-40-8
Molecular Formula

C24H28O4
Molecular Weight (MW) 380.48
SMILES CC1(C)CCC(C)(C)C2=CC(=CC=C12)C3(OCCO3)C4=CC=C(C=C4)C(O)=O
InChIKey ZZUKALQMHNSWTK-UHFFFAOYSA-N

Ordering Information

Biological Activity

SR 11237 is a selective retinoid X receptor (RXR) agonist. Activation of RXR by SR 11237 promotes RXR/RXR homodimer formation and transactivates reporter genes driven by RXR-response elements without activating retinoic acid receptors (RARs). In cellular models, including F9 embryonal carcinoma and HL-60 myeloblastic leukemia cells, RXR activation by SR 11237 modulates gene transcription and cell differentiation, clarifying the distinct pathway functions of RXR homodimers versus RXR/RAR heterodimers.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 38 mg/mL (99.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.