CAS No. 334-50-9

Batch: Purity:98.44
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Spermidine trihydrochloride Chemical Structure
Chemical Structure
Check the Spermidine trihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 334-50-9
Molecular Formula

C7H19N3.3HCl
Molecular Weight (MW) 254.63
SMILES C(CCNCCCN)CN.Cl.Cl.Cl

Biological Activity

Spermidine trihydrochloride is a natural endogenous polyamine that acts as a potent autophagy inducer and negatively modulates N-methyl-D-aspartate (NMDA) receptors. By promoting intracellular autophagy through histone deacetylation and inhibition of histone acetyltransferases, spermidine enhances cellular proteostasis, reduces oxidative stress, and regulates cell survival mechanisms. These downstream effects contribute to attenuated cellular aging and enhanced stress resistance across various biological models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 50 mg/mL
DMSO 25 mg/mL (98.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Eisenberg T, et al. Nat Cell Biol. 2009;11(11):1305-14.

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Note: Technical data last updated: Sep 1, 2026.