CAS No. 449733-84-0
Batch:
Purity:99.7
Chemical Structure
Check the
Specnuezhenide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 449733-84-0 | |
|---|---|---|
| Molecular Formula |
C31H42O17 |
|
| Molecular Weight (MW) | 686.66 | |
| SMILES | CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCC3C(C(C(C(O3)OCCC4=CC=C(C=C4)O)O)O)O |
Biological Activity
Specnuezhenide is a natural iridoid glucoside compound that exhibits anti-angiogenic and retinoprotective activities. It modulates vascular endothelial growth factor (VEGF) pathway signaling to inhibit endothelial cell proliferation, migration, and capillary tube formation. By suppressing pathological neovascularization and maintaining vascular homeostasis, Specnuezhenide attenuates ocular vascular damage and mitigates vision impairment associated with retinal disorders.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(145.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | 7 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.