CAS No. 6160-12-9

Batch: Purity:98
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(-)-Sparteine Sulfate Chemical Structure
Chemical Structure
Check the (-)-Sparteine Sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,2S,9R,10R)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane;sulfuric acid;pentahydrate
CAS Number 6160-12-9
Molecular Formula

C15H26N2.H2SO4.5H2O
Molecular Weight (MW) 422.54
SMILES C1CCN2CC3CC(C2C1)CN4C3CCCC4.O.O.O.O.O.OS(=O)(=O)O
InChIKey WNSDDGBLIALDPB-HTZKOJAYSA-N

Biological Activity

(-)-Sparteine sulfate is a quinolizidine alkaloid that acts as a sodium channel blocker. By inhibiting voltage-gated sodium channels, it suppresses transmembrane sodium influx, leading to reduced action potential conduction velocity and altered membrane excitability. Additionally, (-)-Sparteine sulfate modulates uterine smooth muscle tone and exerts oxytocic activity by regulating cellular ion flux and myometrial contractility pathways.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (201.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.