CAS No. 1454885-45-0

Batch: Purity:99.01
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SP-8356 Chemical Structure
Chemical Structure
Check the SP-8356 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,5R)-4-[(E)-2-(3,4-dihydroxy-5-methoxyphenyl)ethenyl]-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one
CAS Number 1454885-45-0
Molecular Formula

C18H20O4
Molecular Weight (MW) 300.35
SMILES COC1=C(O)C(=CC(=C1)/C=C/C2=CC(=O)C3CC2C3(C)C)O
InChIKey ITCSXIQQWJYZHT-QITAHTHBSA-N

Biological Activity

SP-8356 is a synthetic verbenone derivative that acts as a CDinhibitor. It disrupts CDdimerization and blocks CDinteraction with cyclophilin A, suppressing downstream NF-kB signaling and matrix metalloproteinase-(MMP- activity. These molecular effects lead to reduced breast cancer cell proliferation, migration, and invasion, as well as attenuation of atherosclerotic plaque progression in vivo. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 60 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Mander S, et al. Sci Rep. 2019;9(1):6595.

[2] PahkK, et al. IJMS. 2019;21(1):95.

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Note: Technical data last updated: Sep 1, 2026.