CAS No. 1448440-52-5

Batch: Purity:99.62
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SP-13786 (UAMC-1110) Chemical Structure
Chemical Structure
Check the SP-13786 (UAMC-1110) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
CAS Number 1448440-52-5
Molecular Formula

C17H14F2N4O2
Molecular Weight (MW) 344.32
SMILES C1C(N(CC1(F)F)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N
InChIKey PUOOCZVRHBHJRS-NSHDSACASA-N

Biological Activity

SP-13786 (UAMC-1110) is a potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 ofand prolyl oligopeptidase (PREP) with an IC50 of. By targeting FAP, this compound modulates extracellular matrix degradation and tumor microenvironment remodeling, suppressing cancer-associated fibroblast activity and inhibiting cell migration and invasion. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 69 mg/mL (200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 17 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Jansen K, et al. J Med Chem. 2014;57(7):3053-74.

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Note: Technical data last updated: Sep 1, 2026.