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Sotuletinib (BLZ945) is a potent, brain-penetrant, ATP-competitive CSF-1R inhibitor. It affects CSF1/CSF1R and Akt signaling pathways by binding to the kinase ATP-binding site, inhibiting M2 macrophage polarization and TAM-mediated immunosuppression, and promoting CD8+ T-cell infiltration and myelin preservation.