CAS No. 2383086-06-2

Batch: Purity:
Sonrotoclax (BGB-11417) Chemical Structure
Chemical Structure
Check the Sonrotoclax (BGB-11417) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[4-[(4-hydroxy-4-methylcyclohexyl)methylamino]-3-nitrophenyl]sulfonyl-4-[2-[(2S)-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
CAS Number 2383086-06-2
Molecular Formula

C49H59N7O7S
Molecular Weight (MW) 890.10
InChIKey ZQTKOYMWCCSKON-HCWAPQBJSA-N

Biological Activity

Sonrotoclax (BGB-11417) is an orally active, highly potent, and selective inhibitor of B-cell lymphoma 2 (Bcl-2) that targets both wild-type Bcl-2 and the venetoclax-resistant G101V mutant while showing selectivity over Bcl-xL. By disrupting anti-apoptotic Bcl-2 signaling, it induces mitochondrial apoptosis. Consequently, sonrotoclax exhibits robust cytotoxic activity across diverse leukemia and lymphoma cell lines and effectively suppresses tumor growth in hematologic malignancy models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Liu J, et al. Blood. 2024;143(18):1825-1836.

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Note: Technical data last updated: Sep 1, 2026.