CAS No. 180468-39-7
Batch:
Purity:99.75
Chemical Structure
Check the
Solifenacin hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 180468-39-7 | |
|---|---|---|
| Molecular Formula |
C23H26N2O2.ClH |
|
| Molecular Weight (MW) | 398.93 |
Biological Activity
Solifenacin hydrochloride is a muscarinic receptor antagonist targeting the M1 muscarinic receptor (pKi 7.6), M2 muscarinic receptor (pKi 6.9), and M3 muscarinic receptor (pKi 8.0). By blocking muscarinic receptors, it inhibits G-protein-coupled signaling and intracellular calcium mobilization in response to acetylcholine. This blockade suppresses cholinergic-mediated smooth muscle contraction, particularly reducing urinary bladder detrusor muscle hypercontractility. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 80 mg/mL |
| Ethanol | 80 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.