CAS No. 305-53-3

Sodium iodoacetate(Iodoacetic acid sodium salt) Chemical Structure
Chemical Structure
Check the Sodium iodoacetate(Iodoacetic acid sodium salt) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 305-53-3
Molecular Formula

C2H3IO2.Na
Molecular Weight (MW) 208.94

Biological Activity

Sodium iodoacetate is a covalent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor that blocks glycolytic flux by alkylating the catalytic cysteine residue within the enzyme active site. By disrupting cellular energy metabolism and glycolysis, it impairs ATP production and cell viability. Intra-articular administration of sodium iodoacetate disrupts chondrocyte metabolism, leading to cartilage degeneration and mimicking human osteoarthritis in experimental animal pain models. [1][2]

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Reference

[1] Guingamp C, et al. Arthritis Rheum. 1997;40(9):1670-9.

[2] Bove SE, et al. Osteoarthritis Cartilage. 2003;11(11):821-30.

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Note: Technical data last updated: Sep 1, 2026.