CAS No. 2156-56-1
Batch:
Purity:99.86
Chemical Structure
Check the
Sodium Dichloroacetate (DCA)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | sodium 2,2-dichloroacetate | |
|---|---|---|
| CAS Number | 2156-56-1 | |
| Molecular Formula |
C2HCl2O2.Na |
|
| Molecular Weight (MW) | 150.92 | |
| SMILES | C(C(=O)[O-])(Cl)Cl.[Na+] | |
| InChIKey | LUPNKHXLFSSUGS-UHFFFAOYSA-M |
Sodium Dichloroacetate (DCA) acts as a specific inhibitor of pyruvate dehydrogenase kinase (PDK). Inhibition of PDK derepresses the Na+-K+-2Cl- cotransporter and normalizes the mitochondrial potassium-ion channel axis in cancer cells. Consequently, DCA enhances intracellular reactive oxygen species (ROS) generation, promotes mitochondrial transition pore opening, induces selective apoptosis in cancer cells, and inhibits tumor growth in vivo. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 30 mg/mL |
| Ethanol | 20 mg/mL |
| DMSO |
30 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 30 mg/mL |
| Ethanol | 30 mg/mL |
| DMSO |
30 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 30 mg/mL |
| Ethanol | 30 mg/mL |
| DMSO |
30 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 30 mg/mL |
| Ethanol | 30 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Sodium Dichloroacetate (DCA) Clinical Trials
- Sodium Dichloroacetate (DCA) Solubility in DMSO
- Sodium Dichloroacetate (DCA) Stock Solution
- Sodium Dichloroacetate (DCA) Storage
- Sodium Dichloroacetate (DCA) Stability
- Sodium Dichloroacetate (DCA) Molecular Weight
- Sodium Dichloroacetate (DCA) SMILES
- Sodium Dichloroacetate (DCA) Chemical Structure (2D and 3D)
- Sodium Dichloroacetate (DCA) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.