CAS No. 912545-86-9
Batch:
Purity:99.94
Chemical Structure
Check the
SAG (Smoothened Agonist)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide | |
|---|---|---|
| CAS Number | 912545-86-9 | |
| Molecular Formula |
C28H28ClN3OS |
|
| Molecular Weight (MW) | 490.06 | |
| SMILES | CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(Cl)C5=CC=CC=C5S4 | |
| InChIKey | VFSUUTYAEQOIMW-UHFFFAOYSA-N |
SAG (Smoothened Agonist) is a potent Smoothened (Smo) agonist that induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of. By directly binding to Smo, SAG activates the Hedgehog signaling pathway, promoting the transcription of downstream target genes and driving cell proliferation and differentiation across various cellular contexts. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
| DMSO |
98 mg/mL
(199.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
| DMSO |
98 mg/mL
(199.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- SAG (Smoothened Agonist) Clinical Trials
- SAG (Smoothened Agonist) Solubility in DMSO
- SAG (Smoothened Agonist) Stock Solution
- SAG (Smoothened Agonist) Storage
- SAG (Smoothened Agonist) Stability
- SAG (Smoothened Agonist) Molecular Weight
- SAG (Smoothened Agonist) SMILES
- SAG (Smoothened Agonist) Chemical Structure (2D and 3D)
- SAG (Smoothened Agonist) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.