CAS No. 946262-80-2
Batch:
Purity:99.69
Chemical Structure
Check the
SMIP34
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[1-(4-chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide | |
|---|---|---|
| CAS Number | 946262-80-2 | |
| Molecular Formula |
C20H15ClFN5O2S |
|
| Molecular Weight (MW) | 443.88 | |
| InChIKey | LSXQVMHRXQIQGI-UHFFFAOYSA-N |
SMIP34 is a small-molecule inhibitor targeting proline, glutamic acid, and leucine-rich protein 1 (PELP1). By disrupting PELP1-mediated signaling complexes and downstream oncogenic signaling pathways, SMIP34 effectively reduces cell viability, suppresses cell invasion, and induces apoptosis in triple-negative breast cancer (TNBC) cellular models. These biological activities demonstrate the utility of targeting PELP1 to impair breast cancer proliferation and survival mechanisms. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(6.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.