CAS No. 64987-85-5
Batch:
Purity:99.53
Chemical Structure
Check the
SMCC
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 64987-85-5 | |
|---|---|---|
| Molecular Formula |
C16H18N2O6 |
|
| Molecular Weight (MW) | 334.32 | |
| SMILES | C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CCC3=O |
SMCC is an amine-to-sulfhydryl heterobifunctional crosslinker containing reactive N-hydroxysuccinimide (NHS) ester and maleimide groups for the covalent conjugation of amine- and sulfhydryl-containing biomolecules. By facilitating stable thioether and amide bond formation, SMCC enables the preparation of antibody-drug conjugates and antigen-modified cells, mediating effective target cell recognition and the induction of antigen-specific immune responses. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
67 mg/mL
(200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.