CAS No. 1228105-51-8

Batch: Purity:99.38
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DM1-SMCC Chemical Structure
Chemical Structure
Check the DM1-SMCC product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2,5-dioxopyrrolidin-1-yl) 4-[[3-[3-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylamino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]methyl]cyclohexane-1-carboxylate
CAS Number 1228105-51-8
Molecular Formula

C51H66ClN5O16S
Molecular Weight (MW) 1072.61
InChIKey IADUWZMNTKHTIN-MLSWMBHTSA-N

Biological Activity

DM1-SMCC is an antibody-drug conjugate payload-linker complex composed of the maytansinoid microtubule inhibitor DM1 and the amine-to-sulfhydryl SMCC linker. Upon intracellular release, the DM1 moiety binds to tubulin to disrupt microtubule polymerization and dynamics. This inhibition halts mitotic spindle assembly, driving cell cycle arrest at the G2/M phase and subsequently inducing apoptotic cell death in treated cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (93.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Lewis Phillips GD, et al. Cancer Res. 2008;68(22):9280-90.

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Note: Technical data last updated: Sep 1, 2026.