CAS No. 677773-91-0
Batch:
Purity:99.87
Chemical Structure
Check the
SM 324405
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 677773-91-0 | |
|---|---|---|
| Molecular Formula |
C19H23N5O4 |
|
| Molecular Weight (MW) | 385.42 | |
| SMILES | CCCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=CC(=C3)CC(=O)OC)N |
SM 324405 is a potent and selective Toll-like receptor 7 (TLR7) agonist. Activation of TLR7 stimulates downstream NF-kB signaling pathways and induces the cellular expression of type I interferons and proinflammatory cytokines. These signaling events mediate broader immune system activation, leading to enhanced host antiviral and antitumor innate immune phenotypical responses.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.