CAS No. 2999629-35-3
Batch:
Purity:99.04
Chemical Structure
Check the
SLF1081851 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine;hydrochloride | |
|---|---|---|
| CAS Number | 2999629-35-3 | |
| Molecular Formula |
C21H33N3O.ClH |
|
| Molecular Weight (MW) | 379.97 | |
| InChIKey | ZJJXKBLUUGLWDW-UHFFFAOYSA-N |
Biological Activity
SLF1081851 hydrochloride is a small-molecule inhibitor of spinster homolog 2 (Spns2) that blocks cellular sphingosine-1-phosphate (S1P) release with an IC50 of 1.93 μM [1]. By inhibiting Spns2-mediated S1P transport, SLF1081851 disrupts extracellular S1P gradients required for lymphocyte trafficking [1]. This inhibition reduces circulating plasma S1P concentrations and blood lymphocyte counts in vivo, serving as a chemical probe for studying Spns2 biology and immune modulation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(200.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | 6 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.