CAS No. 1125780-41-7
Batch:
Purity:99.40
Chemical Structure
Check the
SKLB 610
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]pyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 1125780-41-7 | |
| Molecular Formula |
C21H16F3N3O3 |
|
| Molecular Weight (MW) | 415.37 | |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)C(F)(F)F | |
| InChIKey | WACDHHMEVMSODJ-UHFFFAOYSA-N |
SKLB 610 is a multi-target receptor tyrosine kinase inhibitor with high potency against VEGFR2 alongside weaker inhibition of FGFR2 and PDGFR. By suppressing receptor activation and downstream signaling through the MAPK/ERK and PI3K/AKT pathways, SKLB 610 impairs endothelial cell proliferation, survival, and migration. Consequently, inhibition of these kinase signaling networks leads to reduced tumor angiogenesis and impaired vascular structure formation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 27 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.