CAS No. 83-95-4
Batch:
Purity:99.79
Chemical Structure
Check the
Skimmianine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 83-95-4 | |
|---|---|---|
| Molecular Formula |
C14H13NO4 |
|
| Molecular Weight (MW) | 259.26 |
Biological Activity
Skimmianine is a natural furoquinoline alkaloid that exhibits anti-inflammatory, antispastic, and neuroprotective properties [1, 2]. It suppresses the activation of the NF-κB signaling pathway, thereby reducing the production and expression of pro-inflammatory mediators such as TNF-α, IL-6, nitric oxide, and cyclooxygenase-2 (COX-2) [1, 2]. Downstream, these cellular changes attenuate microglial neuroinflammation, decrease systemic acute inflammatory responses, and confer neuroprotective and antiplatelet aggregation effects.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
52 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
13 mg/mL
(50.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.