CAS No. 2070015-29-9
Batch:
Purity:99.24
Chemical Structure
Check the
SJB3-019A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-pyridin-3-ylbenzo[f][1,3]benzoxazole-4,9-dione | |
|---|---|---|
| CAS Number | 2070015-29-9 | |
| Molecular Formula |
C16H8N2O3 |
|
| Molecular Weight (MW) | 276.25 | |
| InChIKey | DOYPPVCQHGJUBC-UHFFFAOYSA-N |
SJB-A is a small-molecule inhibitor of ubiquitin-specific protease 1 (USP1). Pharmacological inhibition of USP1 by SJB-A promotes the degradation of inhibitor of DNA-binding 1 (ID1) in leukemic cells. In B-cell acute lymphoblastic leukemia (B-ALL) cells, USP1 blockade disrupts the ID1/AKT signaling pathway, downregulating p-AKT expression. Consequently, SJB3-019A significantly represses cell proliferation and induces cell apoptosis. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 14 mg/mL |
| DMSO |
7 mg/mL
(25.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.