CAS No. 201677-61-4
Batch:
Purity:99.26
Chemical Structure
Check the
Sivelestat sodium tetrahydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 201677-61-4 | |
|---|---|---|
| Molecular Formula |
C20H21N2O7S.4H2O.Na |
|
| Molecular Weight (MW) | 528.51 | |
| SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+] |
Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase and also inhibits leukocyte elastase from rabbit, rat, hamster, and mouse. By attenuating neutrophil elastase-mediated degradation of extracellular matrix components and vascular endothelial injury, this agent mitigates acute inflammatory responses and tissue damage across preclinical models of acute lung injury and systemic inflammation. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(189.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(189.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Sivelestat sodium tetrahydrate Solubility in DMSO
- Sivelestat sodium tetrahydrate Stock Solution
- Sivelestat sodium tetrahydrate Storage
- Sivelestat sodium tetrahydrate Stability
- Sivelestat sodium tetrahydrate Molecular Weight
- Sivelestat sodium tetrahydrate SMILES
- Sivelestat sodium tetrahydrate Chemical Structure (2D and 3D)
- Sivelestat sodium tetrahydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.