CAS No. 1807758-81-1
Batch:
Purity:99.65
Chemical Structure
Check the
SIRT7 inhibitor 97491
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-N-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine | |
|---|---|---|
| CAS Number | 1807758-81-1 | |
| Molecular Formula |
C15H12ClN3O |
|
| Molecular Weight (MW) | 285.73 | |
| SMILES | NC1=CC=CC(=C1)NC2=NC=C(O2)C3=CC=C(Cl)C=C3 | |
| InChIKey | RMRVZWMKRCLSFX-UHFFFAOYSA-N |
SIRT7 inhibitor 97491 is a potent small-molecule sirtuin 7 (SIRT7) inhibitor that dose-dependently reduces the deacetylase activity of SIRT7 with an ICof. Pharmacological inhibition of SIRT7 enhances p53 stability by promoting p53 acetylation at lysine residues K373 and K382. Consequently, this p53 pathway activation upregulates downstream caspase-mediated apoptotic signaling to effectively suppress tumor progression. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.