CAS No. 3030697-87-8

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SIRT4-IN-1 Chemical Structure
Chemical Structure
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Chemical Information

CAS Number 3030697-87-8
Molecular Formula

C19H13N5O6S3
Molecular Weight (MW) 503.54

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Biological Activity

SIRT4-IN-1 is a cell-permeable inhibitor of Sirtuin 4 (SIRT4) that acts as a competitive inhibitor of acyl peptide substrates by binding directly within the acyl-binding pocket, independently of the NAD+ cofactor. By suppressing SIRT4 activity, it modulates metabolic enzyme regulation, leading to increased glutamate dehydrogenase activity and restored pyruvate dehydrogenase activity to regulate mitochondrial metabolic pathways. [1][2]

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Note: Technical data last updated: Sep 1, 2026.