CAS No. 2079939-05-0

Batch: Purity:99.02
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Sirpiglenastat (DRP-104) Chemical Structure
Chemical Structure
Check the Sirpiglenastat (DRP-104) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name propan-2-yl (2S)-2-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-6-diazo-5-oxohexanoate
CAS Number 2079939-05-0
Molecular Formula

C22H27N5O5
Molecular Weight (MW) 441.48
InChIKey LQNMCWOJACNQQM-PMACEKPBSA-N

Ordering Information

Biological Activity

Sirpiglenastat (DRP-104) is a broad-acting glutamine antagonist prodrug that is preferentially bioactivated in tumor tissue to 6-diazo-5-oxo-L-norleucine (DON). It disrupts canonical cancer metabolism pathways by decreasing glutamine flux into the TCA cycle and inhibiting glutamine-dependent anabolism. Downstream, this metabolic disruption alters the tumor microenvironment by reducing immunosuppressive metabolites and promoting infiltration and activation of tumor-infiltrating T, NK, and M1 macrophage cells. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (199.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 22 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.