CAS No. 4090-18-0

Batch: Purity:99
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Sinoacutine Chemical Structure
Chemical Structure
Check the Sinoacutine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 4090-18-0
Molecular Formula

C19H21NO4
Molecular Weight (MW) 327.37
SMILES CN1CCC23C=C(C(=O)C=C2C1CC4=C3C(=C(C=C4)OC)O)OC

Biological Activity

Sinoacutine (also known as Salutaridine) is a naturally occurring morphinan alkaloid isolated from Sinomenium acutum. As a prominent biosynthetic intermediate in the morphinan alkaloid pathway, it shares structural features with opioid family compounds and exhibits mild antitussive properties. Modulation of central nervous system pathways by morphinan derivatives suppresses the cough reflex and alters downstream neurochemical signaling. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 65 mg/mL (198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Galanie S, et al. Science. 2015;349(6252):1095-100.

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Note: Technical data last updated: Sep 1, 2026.