CAS No. 2306-27-6

Batch: Purity:99.88
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Sinensetin Chemical Structure
Chemical Structure
Check the Sinensetin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2306-27-6
Molecular Formula

C20H20O7
Molecular Weight (MW) 372.37
SMILES COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)OC)OC

Biological Activity

Sinensetin is a natural polymethoxylated flavone with potent anti-angiogenic activity. It effectively suppresses endothelial cell proliferation, migration, and capillary-like tube formation while inducing cell cycle arrest and apoptotic cell death. Furthermore, sinensetin impairs vascular endothelial growth factor signaling pathways, resulting in reduced blood vessel formation and inhibition of angiogenesis in experimental models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 13 mg/mL (34.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.