CAS No. 2480226-06-8

Batch: Purity:99.33
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Simufilam dihydrochloride Chemical Structure
Chemical Structure
Check the Simufilam dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2480226-06-8
Molecular Formula

C15H23Cl2N3O
Molecular Weight (MW) 332.27
SMILES Cl.Cl.CN1CCC2(CC1)NCC(=O)N2CC3=CC=CC=C3

Biological Activity

Simufilam dihydrochloride is an orally active filamin A (FLNA) modulator that preferentially binds an altered conformation of FLNA to restore its native shape. Reversal of FLNA proteopathy disrupts its aberrant linkages with the α7 nicotinic acetylcholine receptor (α7nAChR) and toll-like receptor 4 (TLR4). Consequently, this inhibition prevents amyloid-β42-induced α7nAChR hyperactivation and TLR4 signaling, thereby suppressing tau hyperphosphorylation, neuroinflammation, and synaptic dysfunction. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (198.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 66 mg/mL
Ethanol 4 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Wang HY, et al. Neurobiol Aging. 2017;55:99-114.

[2] Wang HY, et al. J Neurosci. 2012;32(29):9773-84.

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Note: Technical data last updated: Sep 1, 2026.