CAS No. 29782-68-1

Batch: Purity:99.93
Check CoA
Silydianin Chemical Structure
Chemical Structure
Check the Silydianin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,3R,6R,7R,10R)-3-hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R,3R)-3,5,7-trihydroxy-4-oxo-2,3-dihydrochromen-2-yl]-4-oxatricyclo[4.3.1.03,7]dec-8-en-2-one
CAS Number 29782-68-1
Molecular Formula

C25H22O10
Molecular Weight (MW) 482.44
InChIKey CYGIJEJDYJOUAN-JSGXPVSSSA-N

Biological Activity

Silydianin is a bioactive flavonolignan from Silybum marianum that exhibits anti-collagenase and anti-elastase activities to preserve matrix structural integrity. It acts as a free radical scavenger by reducing superoxide radical release and inhibiting lipid peroxidation, while activating caspase-3 to induce neutrophil apoptosis for anti-inflammatory resolution. Downstream, these actions attenuate matrix degradation and suppress oxidative cellular damage to maintain tissue homeostasis.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 96 mg/mL (198.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.