CAS No. 35899-54-8
Batch:
Purity:99.96
Chemical Structure
Check the
SIBA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 35899-54-8 | |
|---|---|---|
| Molecular Formula |
C14H21N5O3S |
|
| Molecular Weight (MW) | 339.41 | |
| SMILES | CC(C)CSCC1OC(C(O)C1O)[N]2C=NC3=C(N)N=CN=C23 |
SIBA is a synthetic analogue of S-adenosylhomocysteine that functions as a selective inhibitor of spermine synthase and biological transmethylation reactions. By blocking aminopropyltransferase activity required for polyamine biosynthesis, SIBA disrupts polyamine metabolism and reduces intracellular macromolecular methylation. These targeted pathway disruptions result in marked antiproliferative effects and the inhibition of cell transformation in rapidly growing cell populations.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(200.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 17 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.