CAS No. 1445987-21-2
Batch:
Purity:99.62
Chemical Structure
Check the
Ivarmacitinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3aS,6aR)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxamide | |
|---|---|---|
| CAS Number | 1445987-21-2 | |
| Molecular Formula |
C₁₈H₂₂N₈O₂S |
|
| Molecular Weight (MW) | 414.49 | |
| InChIKey | DNBCBAXDWNDRNO-FOSCPWQOSA-N |
Ivarmacitinib (SHR0302) is a potent, orally active inhibitor of the Janus kinase family, targeting Janus kinase 1 (JAK1). By selectively inhibiting JAK1, it disrupts downstream JAK/STAT signaling pathways, thereby suppressing the production of key inflammatory cytokines and chemokines. Consequently, ivarmacitinib regulates T cell subset differentiation, reduces chemokine receptor CXCR3 expression, and exhibits robust anti-inflammatory and anti-proliferative cellular biological activity. [1]
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Concentration
Volume
Mass
|
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.