CAS No. 914805-33-7

Batch: Purity:99.02
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Shield-1 (Shld1) Chemical Structure
Chemical Structure
Check the Shield-1 (Shld1) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1R)-3-(3,4-dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
CAS Number 914805-33-7
Molecular Formula

C42H56N2O10
Molecular Weight (MW) 748.90
InChIKey NMFHJNAPXOMSRX-PUPDPRJKSA-N

Ordering Information

Biological Activity

Shield-1 is a cell-permeable, high-affinity ligand targeting mutated FK506-binding protein 12 (FKBP). By selectively binding to the destabilizing domain of mutated FKBP, Shield-1 protects mtFKBP-fused proteins from proteasomal degradation. This ligand-dependent stabilization enables rapid, reversible, and tunable control over target protein expression and downstream biological pathways in living cells and animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (133.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.