CAS No. 64421-28-9

Batch: Purity:99.89
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Shanzhiside methyl ester Chemical Structure
Chemical Structure
Check the Shanzhiside methyl ester product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 64421-28-9
Molecular Formula

C17H26O11
Molecular Weight (MW) 406.38
SMILES CC1(CC(C2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O)O

Ordering Information

Biological Activity

Shanzhiside methyl ester is an iridoid glycoside that acts as a small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist. Activation of GLP-1 receptor signaling modulates intracellular cyclic AMP levels and downstream pathway cascades, leading to reduced neuroinflammation and suppression of nociceptive signaling. Through these GLP-1 receptor-mediated mechanisms, the compound demonstrates significant anti-inflammatory and antinociceptive activity in preclinical models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (199.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.