CAS No. 2226517-76-4
Batch:
Purity:99.96
Chemical Structure
Check the
SGC-GAK-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine | |
|---|---|---|
| CAS Number | 2226517-76-4 | |
| Molecular Formula |
C18H17BrN2O3 |
|
| Molecular Weight (MW) | 389.24 | |
| SMILES | COC1=CC(=CC(=C1OC)OC)NC2=C3C=C(C=CC3=NC=C2)Br | |
| InChIKey | AUOSKLDNVNGKRR-UHFFFAOYSA-N |
SGC-GAK-1 is a selective and cell-active inhibitor of cyclin G-associated kinase (GAK) with greater than 50-fold selectivity over adjacent kinases. By inhibiting GAK, it blocks clathrin-mediated endocytosis and regulates intracellular vesicle trafficking pathways. Inhibition of GAK interrupts endocytic cargo transport and disrupts viral entry mechanisms, establishing SGC-GAK-1 as a potent chemical probe for investigating GAK-dependent signaling and cellular functions. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 39 mg/mL |
| Water | Insoluble |
| DMSO |
78 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.