CAS No. 1174428-47-7
Batch:
Purity:99.04
Chemical Structure
Check the
SF2523
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one | |
|---|---|---|
| CAS Number | 1174428-47-7 | |
| Molecular Formula |
C19H17NO5S |
|
| Molecular Weight (MW) | 371.41 | |
| SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C(=CS3)C4=CC5=C(C=C4)OCCO5 | |
| InChIKey | BYTKNUOMWLJVNQ-UHFFFAOYSA-N |
SF2523 is a potent dual inhibitor of phosphoinositide 3-kinase (PI3K) and bromodomain-containing protein 4 (BRD4). It simultaneously suppresses PI3K/AKT/mTOR signaling and BRD4-driven transcriptomic programs, leading to the downregulation of MYC expression. Consequently, treatment with SF2523 disrupts cancer cell proliferation, induces cell cycle arrest and apoptosis, and effectively impairs tumor growth and metastasis in MYC-driven preclinical cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(78.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.