CAS No. 2417395-15-2
Chemical Structure
Check the
Sevasemten
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(5-fluoro-3-pyridinyl)methyl]-6-[2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl]pyridazin-3-one | |
|---|---|---|
| CAS Number | 2417395-15-2 | |
| Molecular Formula |
C16H11F4N5O2 |
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| Molecular Weight (MW) | 381.29 | |
| InChIKey | XFPJKQRXBAFXNK-UHFFFAOYSA-N |
Sevasemten is a selective, orally active allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. It reduces biomarkers of muscle damage and fibrosis while enhancing muscle strength and functional activity in models of Duchenne muscular dystrophy. Allosteric modulation of muscle myosin represents an established therapeutic strategy to mitigate pathological hyper-contractility and muscle degeneration. [1]
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Note: Technical data last updated: Sep 1, 2026.