CAS No. 1619931-27-9

Batch: Purity:99.82
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Seralutinib (GB002) Chemical Structure
Chemical Structure
Check the Seralutinib (GB002) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-[(1S)-1-[[6-(3,4-dimethoxyphenyl)pyrazin-2-yl]amino]ethyl]phenyl]-5-methylpyridine-3-carboxamide
CAS Number 1619931-27-9
Molecular Formula

C27H27N5O3
Molecular Weight (MW) 469.54
SMILES COC1=C(OC)C=C(C=C1)C2=CN=CC(=N2)NC(C)C3=CC(=CC=C3)NC(=O)C4=CN=CC(=C4)C
InChIKey JHJNPOSPVGRIAN-SFHVURJKSA-N

Ordering Information

Biological Activity

Seralutinib (GB002) is a novel small-molecule receptor tyrosine kinase inhibitor that potently targets PDGFRα and PDGFRβ. It additionally inhibits c-KIT and CSF1R signaling, thereby suppressing downstream proliferative and inflammatory pathways while restoring lung BMPR2 expression. These combined cellular actions attenuate pulmonary artery smooth muscle cell proliferation and vascular remodeling, resulting in reduced pulmonary artery muscularization and right ventricular hypertrophy in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (200.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 94 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.