CAS No. 81-27-6

Batch: Purity:99.97
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Sennoside A Chemical Structure
Chemical Structure
Check the Sennoside A product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
CAS Number 81-27-6
Molecular Formula

C42H38O20
Molecular Weight (MW) 862.74
SMILES C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)OC7C(C(C(C(O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
InChIKey IPQVTOJGNYVQEO-KGFNBKMBSA-N

Ordering Information

Biological Activity

Sennoside A is a naturally occurring anthraquinone glycoside and irritant laxative isolated from Rhei Rhizoma that displays purgative activity in the intestine. It is metabolized by intestinal microbiota into rhein anthrone, which acts on the colon to stimulate peristalsis and inhibit fluid absorption. Mechanistically, sennoside A downregulates aquaporin 3 (AQP3) expression in mucosal epithelial cells, leading to decreased mucosal water reabsorption and promoted fecal excretion. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 2 mg/mL (2.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.