CAS No. 94596-28-8

Batch: Purity:99.89
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Senkyunolide I Chemical Structure
Chemical Structure
Check the Senkyunolide I product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3Z,6S,7S)-3-butylidene-6,7-dihydroxy-4,5,6,7-tetrahydro-2-benzofuran-1-one
CAS Number 94596-28-8
Molecular Formula

C12H16O4
Molecular Weight (MW) 224.25
SMILES CCC\C=C1/OC(=O)C2=C1CCC(O)C2O
InChIKey DQNGMIQSXNGHOA-JXQVETIVSA-N

Ordering Information

Biological Activity

Senkyunolide I is a bioactive natural phthalide isolated from Ligusticum chuanxiong with potent neuroprotective, anti-oxidative, and anti-apoptotic activities. It stimulates the phosphorylation of ERK1/2 and promotes Nrf2 nuclear translocation, leading to increased downstream expression of antioxidant enzymes including HO-1 and NQO1. Furthermore, senkyunolide I increases the Bcl-2/Bax expression ratio and suppresses the expression of cleaved caspase-3 and caspase-9, thereby mitigating cellular oxidative stress and apoptotic cell death.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (445.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water 33 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.